There is a need to increase the scope of closed-loop optimization to a broader envelope and close the gaps between organizational silos responsible for optimization. Many companies have turned their attention to real-time end-to-end optimization of an entire facility and enterprise. What is quickly realized, however, is that the problem is exponentially challenging due to the sheer number of manipulated and controlled variables, complex interdependency, time scale difference, and non-linear relationship, as well as the requirement of constraint prioritization, feasible solutions, and effective performance monitoring for sustained benefits.