Refiners continuously search for the best available options to maximize the return on investment for purchases. Since catalyst purchases are reoccurring and typically planned, these investments are critical to meeting financial targets. The optimum catalyst solution may incorporate different amounts of existing catalysts, replacement of one catalyst for another, or possibly a new, innovative catalyst approach to meeting refinery objectives. This paper examines three different refinery intentions related to catalyst selection for an upcoming hydrocracking unit reload: 1) reducing catalyst spend, 2) improving steady state operation, and 3) meeting new refinery objectives.